Preliminary studies for the establishment of a model of lung colonization caused by Pseudomonas aeruginosa in piglets - Perspectives of application in the CFTR-deficient piglets

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Chevaleyre, Claire, C. | Riou, Mickaël | Berri, El Mostafa | Cognie, Juliette | Venturi, Eric | Lardy, H. | Villemagne, T. | Moënne-Loccoz, J. | Winter, Nathalie | Gauthier, F. | Schwartz, Bertrand | Bahr, A. | Wolf, E. | Ramphal, R. | Attucci, S. | Buzoni-Gatel, Dominique | Si-Taha, M. | Sarradin, Pierre | Brea, D. | Olivier, Michel | Guillon, Antoine | Meurens, Francois | Barc, Celine

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National audience. Conclusions: The cause of death of the CFTR KO piglets is not currently known, and we are still improving the post-operative cares. As the incidence of meconium ileus is of 100% in CFTR -/- animals, the diagnosis could be done faster by CT scan (and confirmed later by the PCR). By reducing the birth-to-surgery time, we hope to improve the survival. The tissues that we have collected provide an original opportunity to investigate initiating mechanisms of disease, with CF and non-CF comparisons, but without confounders.

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