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On the importance of evolutionary constraint for regulatory sequence identification

Archive ouverte | Giudicelli, François | CCSD

International audience. Regulation of gene expression relies on the activity of specialized genomic elements, enhancers or silencers, distributed over sometimes large distance from their target gene promoters. A sig...

On the importance of evolutionary constraint for regulatory sequence identification

Archive ouverte | Giudicelli, François | CCSD

International audience. Abstract Regulation of gene expression relies on the activity of specialized genomic elements, enhancers or silencers, distributed over sometimes large distance from their target gene promote...

Nucleosome rotational setting is associated with transcriptional regulation in promoters of tissue-specific human genes.

Archive ouverte | Hebert, Charles | CCSD

International audience. BACKGROUND: The position of a nucleosome, both translational along the DNA molecule and rotational between the histone core and the DNA, is controlled by many factors, including the regular o...

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