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AAV serotype testing on cultured human donor retinal explants

Archive ouverte | Buck, Thilo M. | CCSD

International audience. This protocol details on a screening method for infectivity and tropism of different serotypes of adeno-associated viruses (AAVs) on human retinal explants with cell-type specific or ubiquito...

The CRB1 and adherens junction complex proteins in retinal development and maintenance

Archive ouverte | Alves, Celso Henrique | CCSD

International audience. The early developing retinal neuroepithelium is composed of multipotent retinal progenitor cells that differentiate in a time specific manner, giving rise to six major types of neuronal and o...

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.

Archive ouverte | Alves, Celso Henrique | CCSD

International audience. In humans, the Crumbs homolog-1 (CRB1) gene is mutated in progressive types of autosomal recessive retinitis pigmentosa and Leber congenital amaurosis. However, there is no clear genotype-phe...

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