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Structurally related odorant ligands of the olfactory receptor OR51E2 differentially promote metastasis emergence and tumor growth

Archive ouverte | Sanz, Guenhaël | CCSD

Olfactory receptors are G protein-coupled receptors. Some of them are expressed in tumor cells, such as the OR51E2 receptor overexpressed in LNCaP prostate cancer cells. It is considered a prostate tumor marker. We previously demo...

Stimulation of olfactory receptors expressed in cancer cells promotes their invasiveness and proloferation, leading ton increased metastasis emergence in vivo

Archive ouverte | Sanz, Guenhaël | CCSD

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Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand

Archive ouverte | Sanz, Guenhaël | CCSD

International audience. We previously reported that the olfactory receptor OR51E2, overexpressed in LNCaP prostate cancer cells, promotes cell invasiveness upon stimulation of its agonist β-ionone, and this phenomen...

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