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Exploring the effects of tetrahydrobiopterin on motivation, dopamine release and acute inflammation in mice

Archive ouverte | Fanet, Hortense | CCSD

International audience. Inflammation can affect mesodopaminergic system and mediates depressive symptoms related to motivation and locomotion. Precisely, pro-inflammatory cytokines can alter dopamine synthesis and t...

Decrease in operant responding under obesogenic diet exposure is not related to deficits in incentive or hedonic processes

Archive ouverte | Ducrocq, Fabien | CCSD

International audience. Objective A growing body of evidence suggests that obesity could result from alterations in reward processing. In rodent models, chronic exposure to an obesogenic diet leads to blunted dopami...

Tetrahydrobiopterin as a potential treatment for Alzheimer’s disease: A study in 3xTg-AD mice

Archive ouverte | Calon, F. | CCSD

International audience. Alzheimer’s disease (AD) is a multifactorial disease, thus multi-target treatments are needed. Tetrahydrobiopterin (BH4) has been shown to be decreased in elderly and in AD patients. BH4 is a...

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