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Cellular study of a bacterial DNA-damaging virulence factor, the Cytolethal Distending Toxin

Archive ouverte | Pons, Benoît | CCSD

National audience. Genotoxic agents alter the genetic information by damaging DNA inside living cells, leading to genetic instability and carcinogenesis. Several bacteria from the human microbiota produce genotoxic ...

Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B

Archive ouverte | Pons, Benoît | CCSD

International audience. The Cytolethal Distending Toxin (CDT) is produced by many Gram-negative pathogenic bacteria responsible for major foodborne diseases worldwide. CDT induces DNA damage and cell cycle arrest in...

Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not

Archive ouverte | Pons, Benoît | CCSD

International audience. The Cytolethal Distending Toxin (CDT) is produced by many pathogenic bacteria. CDT is known to induce genomic DNA damage to host eukaryotic cells through its catalytic subunit, CdtB. CdtB is ...

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