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TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends

Archive ouverte | Bombarde, Oriane | CCSD

DNA-dependent protein kinase (DNA-PK) is a double-strand breaks repair complex, the subunits of which (KU and DNA-PKcs) are paradoxically present at mammalian telomeres. Telomere fusion has been reported in cells lacking these pro...

BRCA1 prevents R-loop-associated centromeric instability

Archive ouverte | Racca, Carine | CCSD

International audience. Abstract Centromeres are defined by chromatin containing the histone H3 variant CENP-A assembled onto repetitive α-satellite sequences, which are actively transcribed throughout the cell cycl...

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction

Archive ouverte | Kefala Stavridi, Antonia | CCSD

International audience. The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals for repairing endogenous, accidental or programmed DNA Double-Strand Breaks. c-NHEJ is regulate...

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