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Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics

Archive ouverte | Laferrière, Florent | CCSD

International audience. Prions are proteinaceous infectious agents responsible for fatal neurodegenerative diseases in animals and humans. They are essentially composed of PrPSc, an aggregated, misfolded conformer o...

Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification

Archive ouverte | Moudjou, Mohammed, M. | CCSD

International audience. Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuabl...

Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions

Archive ouverte | Chapuis, Jerome | CCSD

International audience. Introduction: Mammalian prions are proteinaceous pathogens responsible for a broad range of fatal neurodegenerative diseases in humans and animals. These diseases can occur spontaneously, suc...

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