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Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification

Archive ouverte | Moudjou, Mohammed, M. | CCSD

International audience. Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuabl...

Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics

Archive ouverte | Laferrière, Florent | CCSD

International audience. Prions are proteinaceous infectious agents responsible for fatal neurodegenerative diseases in animals and humans. They are essentially composed of PrPSc, an aggregated, misfolded conformer o...

Glycoform-independent prion conversion by highly efficient, cell-based, protein misfolding cyclic amplification

Archive ouverte | Moudjou, Mohammed, M. | CCSD

International audience. Prions are formed of misfolded assemblies (PrPSc) of the variably N-glycosylated cellular prion protein (PrPC). In infected species, prions replicate by seeding the conversion and polymerizat...

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