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Prion strain-dependent tropism is maintained between spleen and granuloma and relies on lymphofollicular structures

Archive ouverte | Al-Dybiat, Iman | CCSD

International audience. In peripherally acquired prion diseases, prions move through several tissues of the infected host, notably in the lymphoid tissue, long before the occurrence of neuroinvasion. Accumulation ca...

Prion species barriers: studies with atypical scrapie and prions from pure synthetic origin

Archive ouverte | Béringue, Vincent | CCSD

International audience

Species barrier as molecular basis for adaptation of synthetic prions with N‐terminally truncated PrP

Archive ouverte | Rezaei, Human | CCSD

International audience. Mammalian prions are neurotropic pathogens formed from PrP Sc assemblies, a misfolded variant of the host‐encoded prion protein PrP C . Multiple PrP Sc conformations or strains self‐propagate...

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