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Generation of cattle knockout for galactose‐α1,3‐galactose and N‐glycolylneuraminic acid antigens

Archive ouverte | Perota, Andrea | CCSD

International audience. Two well-characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc) which are intr...

Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs

Archive ouverte | Salama, Apolline | CCSD

International audience. Xenocell therapy from neonate or adult pig pancreatic islets is one of the most promising alternatives to allograft in type 1 diabetes for addressing organ shortage. In humans, however, natur...

Immune phenotype and IgG characteristics of Neu5Gc and alpha-1-3-gal double knock-out pigs

Archive ouverte | Salama, Apolline | CCSD

International audience

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