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Induction of partial protection in mice after oral administration of Lactococcus lactis producing Brucella abortus L7/L12 antigen.

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Pontes, Daniela S | Dorella, Fernanda A | Ribeiro, Luciana A | Miyoshi, Anderson | Le Loir, Yves | Gruss, Alexandra, A. | Oliveira, Sergio C | Langella, Philippe, P. | Azevedo, Vasco

Edité par CCSD ; Informa Healthcare -

International audience. The Brucella abortus ribosomal protein L7/L12 is an immunodominant antigen and an interesting candidate for the development of oral live vaccines against brucellosis. Here, a recombinant Lactococcus lactis strain producing L7/L12 under the control of nisin inducible promoter was orally administered to BALB/c mice. Significant levels of anti-L7/L12 specific IgA detected in feces revealed an induced local humoral immune response. However, serum analysis did not reveal any anti-L7/L12 antibodies suggesting the absence of a systemic response. Nevertheless, the vaccinated mice showed a partial protective immunity against B. abortus virulent strain (S2308) challenged by intraperitoneal inoculation.

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