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Mutations lowering the phosphatase activity of HPr kinase / phosphatase switch off carbon metabolism

Archive ouverte | Monedero, V. | CCSD

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X-ray structure of a bifunctional protein kinase in complex with its protein substrate HPr

Archive ouverte | Fieulaine, S. | CCSD

International audience. HPr kinase/phosphorylase (HprK/P) controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by Gram-positive bacteria. It catalyzes ...

Pyrophosphate-producing protein dephosphorylation by HPr kinase/phosphorylase: A relic of early life?

Archive ouverte | Mijakovic, I. | CCSD

International audience. In most Gram-positive bacteria, serine-46-phosphorylated HPr (P-Ser-HPr) controls the expression of numerous catabolic genes ( approximately 10% of their genome) by acting as catabolite corep...

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