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The Expression of Aromatase in Gonadotropes Is Regulated by Estradiol and Gonadotropin-Releasing Hormone in a Manner that Differs from the Regulation of Luteinizing Hormone

Archive ouverte | Galmiche, Guillaume | CCSD

International audience. The role of estrogens is dual: they suppress basal expression of gonadotropins and enhance GnRH responsiveness at the time of the LH surge. Estrogens are synthesized by cytochrome P450 aromat...

Aromatase gene expression and regulation in the female rat pituitary

Archive ouverte | Galmiche, Guillaume | CCSD

International audience

Aromatase Gene Expression and Regulation in the Female Rat Pituitary

Archive ouverte | Galmiche, Guillaume | CCSD

International audience. Aromatase cytochrome P450, the key enzyme of estrogen biosynthesis from androgens, is encoded by CYP19. Its structure shows some peculiarities: exons II to X encode the protein, while multipl...

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