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LipA, a tyrosine and lipid phosphatase involved in the virulence of Listeria monocytogenes

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Kastner, Renate | Dussurget, Olivier | Archambaud, Cristel | Kernbauer, Elisabeth | Soulat, Didier | Cossart, Pascale | Decker, Thomas

Edité par CCSD ; American Society for Microbiology -

International audience. Intracellular bacterial pathogens manipulate host cell functions by producing enzymes that stimulate or antagonize signal transduction. The Listeria monocytogenes genome contains a gene, lmo1800, encoding a protein with a conserved motif of conventional tyrosine phosphatases. Here, we report that the lmo1800-encoded protein LipA is secreted by Listeria and displays tyrosine as well as lipid phosphatase activity in vitro. Bacteria lacking LipA are severely attenuated in virulence in vivo, thus revealing a so-far-undescribed enzymatic activity involved in Listeria infection.

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