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The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

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Huang, Yinhua | Li, Yingrui | Burt, David W | Chen, Hualan | Zhang, Yong | Qian, Wubin | Kim, Heebal | Gan, Shangquan | Zhao, Yiqiang | Li, Jianwen | Yi, Kang | Feng, Huapeng | Zhu, Pengyang | Li, Bo | Liu, Qiuyue | Fairley, Suan | Magor, Katharine E | Du, Zhenlin | Hu, Xiaoxiang | Goodman, Laurie | Tafer, Hakim | Vignal, Alain | Lee, Taeheon | Kim, Kyu-Won | Sheng, Zheya | An, Yang | Searle, Steve | Herrero, Javier | Groenen, Martien a M | Crooijmans, Richard P M A | Faraut, Thomas | Cai, Qingle | Webster, Robert G | Aldridge, Jerry R | Warren, Wesley C | Bartschat, Sebastian | Kehr, Stephanie | Marz, Manja | Stadler, Peter F | Smith, Jacqueline | Kraus, Robert H S | Zhao, Yaofeng | Ren, Liming | Fei, Jing | Morisson, Mireille | Kaiser, Pete | Griffin, Darren K | Rao, Man | Pitel, Frederique | Wang, Jun | Li, Ning

Edité par CCSD ; Nature Publishing Group -

Chantier qualité GA "Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access ". International audience. The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.

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