Evidence for Network Evolution in an Arabidopsis Interactome Map
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Braun, Pascal | Carvunis, Anne-Ruxandra | Charloteaux, Benoit | Dreze, Matija | Ecker, Joseph R. | Hill, David E. | Roth, Frederick P. | Vidal, Marc | Galli, Mary | Balumuri, Padmavathi | Bautista, Vanessa | Chesnut, Jonathan D. | Kim, Rosa Cheuk | de Los Reyes, Chris | Gilles, Patrick | Kim, Christopher J. | Matrubutham, Uday | Mirchandani, Jyotika | Olivares, Eric | Patnaik, Suswapna | Quan, Rosa | Ramaswamy, Gopalakrishna | Shinn, Paul | Swamilingiah, Geetha M. | Wu, Stacy | Byrdsong, Danielle | Dricot, Amélie | Duarte, Melissa | Gebreab, Fana | Gutierrez, Bryan J. | Macwilliams, Andrew | Monachello, Dario | Mukhtar, M. Shahid | Poulin, Matthew M. | Reichert, Patrick | Romero, Viviana | Tam, Stanley | Waaijers, Selma | Weiner, Evan M. | Cusick, Michael E. | Taşan, Murat | Yazaki, Junshi | Ahn, Yong-Yeol | Barabási, Albert-László | Chen, Huaming | Dangl, Jeffery L. | Fan, Changyu | Gai, Lantian | Ghoshal, Gourab | Hao, Tong | Lurin, Claire | Milenkovic, Tijana | Moore, Jonathan | Pevzner, Samuel J. | Przulj, Natasa | Rabello, Sabrina | Rietman, Edward A. | Rolland, Thomas | Santhanam, Balaji | Schmitz, Robert J. | Spooner, William | Stein, Joshua | Vandenhaute, Jean | Ware, Doreen
Edité par
CCSD ; American Association for the Advancement of Science (AAAS) -
International audience.
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
