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Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists

Archive ouverte | Devavry, Séverine | CCSD

Melatonin receptors have been described to activate different G proteindependent signaling pathways, both in laboratory, heterologous, cellular models and in physiological conditions. Furthermore, the constitutive activity of G pr...

Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state

Archive ouverte | Legros, Céline | CCSD

Melatonin receptors have been extensively characterized regarding their affinity and pharmacology, mostly using 2-[(125) I]-melatonin as a radioligand. Although [(3) H]-melatonin has the advantage of corresponding to the endogenou...

Hamster Melatonin Receptors: Cloning and Binding Characterization of MT₁ and Attempt to Clone MT₂.

Archive ouverte | Gautier, Célia | CCSD

International audience. For many years, it was of interest to identify the sequences encoding the two melatonin receptors (MT₁ and MT₂) from various species. After publishing the basic molecular characterization of ...

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