Bronchiolo-alveolar carcinoma and lung transplantation

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Avrillon, V. | Philit, F. | Chalabreysse, L. | Chumbi-Flores, R. -W. | Tronc, F. | Thivolet-Bejui, Françoise | Mornex, Jean-François

Edité par CCSD ; Elsevier Masson -

National audience. Introduction. - Bronchiolo-alveolar carcinoma is a controversial indication for lung transplantation because of the risk of recurrence. We report three cases and propose some risk factors for recurrence. Case reports. - Our study concerns three patients transplanted at the Louis-Pradel Hospital between 1991 and 2010. The first patient relapsed 86 months after transplantation, benefited from surgical treatment, then died of renal failure. A second patient died of infection, without recurrence, 72 months after transplantation. The third had an early recurrence at 7 months and died 27 months after transplantation. The risk factors for recurrence appear to be: clinically "aggressive" presentation and histological stromal pulmonary invasion by the carcinoma. Conclusion. - Diffuse bronchiolo-alveolar carcinoma is a possible indication of lung transplantation. The risk of recurrence imposes some requirements: a precise histological diagnosis and a slow clinical course. (C) 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved.

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