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Glycosylphosphatidylinositols of Toxoplasma gondii induce matrix metalloproteinase-9 production and degradation of galectin-3

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Niehus, Sebastian | Elass, Elisabeth | Coddeville, Bernadette | Guerardel, Yann | Schwarz, Ralph T | Debierre-Grockiego, Françoise

Edité par CCSD ; Elsevier -

International audience. Toxoplasma gondii glycosylphosphatidylinositols (GPIs) bind to galectin-3 to induce TNF-α production in macrophages via Toll-like receptors 2 and 4. Here we show that T. gondii GPIs stimulate human macrophages to synthesize matrix metalloproteinase-9 in a TNF-α-dependent pathway and degrade extracellular galectin-3.

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