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Unusual compounds from Galium mollugo and their inhibitory activities against ROS generation in human fibroblasts.

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Chaher, Nassima | Krisa, Stéphanie | Delaunay, Jean-Claude | Bernillon, Stéphane | Pedrot, Eric | Merillon, Jean-Michel | Atmani, Djebbar | Richard, Tristan

Edité par CCSD ; Elsevier -

International audience. Three unusual dioxatricyclodecenone compounds, mollugoside A, E-mollugoside B and Z-mollugoside B and, together with known flavonoids, were isolated from the aerial parts of Galium mollugo collected in north-eastern Algeria. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Flavonoids and mollugoside A significantly reduced reactive oxygen species (ROS) generation in human fibroblasts.

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