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Association of severe placental inflammation with death prior to discharge and cerebral palsy in preterm infants.
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International audience. Objective The objective of our study was to identify placentalpatterns associated with death before discharge or cerebral palsyin a large cohort of preterm infants with a high follow-up rate at2 years of corrected age. Design: Population-based monocentric study. Settings: Monocentric study in the maternity unit of the UniversityHospital of Angers, France between 24+0and 33+6weeks ofgestation, between January 2008 and December 2011. Population: All singleton infants born alive with a placentalexamination were eligible. Methods Clinical data (obstetric and neonatal) were collectedprospectively through the LIFT cohort. Placental data werecollected retrospectively from medical records. The main outcomemeasure was death before discharge or cerebral palsy. Results: We did not find any significant association between severeinflammatory lesions on the placenta and death [odds ratio (OR)1.49; 95% CI 0.55– 4.01; P = 0.43] or cerebral palsy (OR 1.41;95% CI 0.43–4.62; P = 0.57). This lack of significant associationpersisted even after adjustment (aOR 0.9; 95% CI 0.20–2.30;P = 0.54; aOR 0.98; 95% CI 0.27–3.58; P = 0.97).We did not find any significant association between severeinflammatory lesions on the placenta and death [odds ratio (OR)1.49; 95% CI 0.55– 4.01; P = 0.43] or cerebral palsy (OR 1.41;95% CI 0.43–4.62; P = 0.57). This lack of significant associationpersisted even after adjustment (aOR 0.9; 95% CI 0.20–2.30;P = 0.54; aOR 0.98; 95% CI 0.27–3.58; P = 0.97). Conclusion: Our results do not provide evidence for a significantassociation between severe inflammatory placental lesions andeither death before discharge or cerebral palsy at 2 years ofcorrected age in preterm infants born at <34 weeks of gestationalage. Further studies remain necessary to confirm this result.Conclusion Our results do not provide evidence for a significantassociation between severe inflammatory placental lesions andeither death before discharge or cerebral palsy at 2 years ofcorrected age in preterm infants born at <34 weeks of gestationalage. Further studies remain necessary to confirm this result.
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