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Low-density lipoprotein receptor on endothelium of brain capillaries

Archive ouverte | Méresse, Stéphane | CCSD

International audience. The presence of lipoproteins, apolipoproteins, and their receptors in the brain could provide a system for cholesterol homeostasis, as they do in other tissues. This study was undertaken to d...

Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes

Archive ouverte | Dehouck, Bénédicte | CCSD

International audience. In contrast to the endothelial cells in large vessels where LDL receptors are downregulated, brain capillary endothelial cells in vivo express an LDL receptor. Using a cell culture model of t...

Peroxisome Proliferator-activated Receptor α (PPARα) Turnover by the Ubiquitin-Proteasome System Controls the Ligand-induced Expression Level of Its Target Genes

Archive ouverte | Blanquart, Christophe | CCSD

International audience. Peroxisome proliferator activated-receptor α (PPARα) is a ligand-activated transcription factor belonging to the nuclear receptor family. PPARα is implicated in the regulation of lipid and gl...

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