Prevalence and clinical outcomes of poor immune response despite virologically suppressive antiretroviral therapy among children and adolescents with human immunodeficiency virus in Europe and Thailand: cohort study *
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Jourdain, Gonzague | Soriano-Arandes, Antoni | Collins, Intira | Marqués, Laura | Chiappini, Elena | Galli, Luisa | Naver, Lars | Gibb, Diana | Marczynska, Magdalena | Lallemant, Marc | Ngo-Giang-Huong, Nicole | Malyuta, Ruslan | Volokha, Alla | Goetghebuer, Tessa | Hainaut, Marc | Delforge, Marc | Warszawski, Josiane | Le Chenadec, Jérôme | Ramos, Elisa | Dialla, Olivia | Wack, Thierry | Laurent, Corine | Ait Si Selmi, Lamya | Leymarie, Isabelle | Ait Benali, Fazia | Brossard, Maud | Boufassa, Leila | Floch-Tudal, Corinne | Firtion, Ghislaine | Hau, Isabelle | Chace, Anne | Bolot, Pascal | Blanche, Stephane | Levine, Martine | Bicëtre, Le Kremlin | Fourcade, Corinne | Heller-Roussin, Brigitte | Runel-Belliard, Camille | Tricoire, Joëlle | Chirouze, Catherine | Reliquet, Véronique | Brouard, Jacques | Kebaili, Kamila | Fialaire, Pascale | Lalande, Muriel | Schultze-Strasser, Stephan | Baumann, U | Niehues, T | Neubert, J | Kobbe, R | Berlin, Charite | Feiterna-Sperling, C | Königs, Christoph | Buchholz, B | Notheis, G | Spoulou, Vana | de Martino, Maurizio | Angelo Tovo, Pier | Patrizia, Osimani | Larovere, Domenico | Ruggeri, Maurizio | Faldella, Giacomo | Baldi, Francesco | Badolato, Raffaele | Montagnani, Carlotta | Venturini, Elisabetta | Lisi, Catiuscia | Di Biagio, Antonio | Taramasso, Lucia | Giacomet, Vania | Erba, Paola | Esposito, Susanna | Lipreri, Rita | Salvini, Filippo | Tagliabue, Claudia | Cellini, Monica | Bruzzese, Eugenia | Lo Vecchio, Andrea | Rampon, Osvalda | Donà, Daniele | Romano, Amelia | Dodi, Icilio | Maccabruni, Anna | Consolini, Rita | Bernardi, Stefania | Tchidjou Kuekou, Hyppolite | Genovese, Orazio | Olmeo, Paolina | Cristiano, Letizia | Mazza, Antonio | Gabiano, Clara | Garazzino, Silvia | Pellegatta, Antonio | Pajkrt, D | Scherpbier, Henriette | Weijsenfeld, A | de Boer, C. | Jurriaans, S | Back, N | Zaaijer, H | Berkhout, B. | Cornelissen, M | Schinkel, C | Wolthers, K | Fraaij, P | van Rossum, A | van Der Knaap, L | Visser, E | Koopmans, M. | van Kampen, J | Pas, S | Henriet, S. | van de Flier, M | van Aerde, K | Strik-Albers, R | Rahamat-Langendoen, J | Stelma, F | Schölvinck, E | de Groot-de Jonge, H | Niesters, H | van Leer-Buter, C | Knoester, M | Bont, L | Geelen, S | Wolfs, T | Nauta, N | Ang, C | van Houdt, R | Pettersson, A | Vandenbroucke-Grauls, C | Reiss, P. | Bezemer, D | van Sighem, A | Smit, Colette | Wit, F | Boender, T | Zaheri, S | Hillebregt, M | de Jong, A | Bergsma, D | Grivell, S | Jansen, A | Raethke, M | Meijering, R | de Groot, L | van den Akker, M | Bakker, Y | Claessen, E | El Berkaoui, A | Koops, J | Kruijne, E | Lodewijk, C | Munjishvili, L | Peeck, B | Ree, C | Regtop, R | Ruijs, Y | Rutkens, T | Schoorl, M | Timmerman, A | Tuijn, E | Veenenberg, L | van Der Vliet, S | Wisse, A | Woudstra, T | Tuk, B | Popielska, Jolanta | Pokorska-Śpiewak, Maria | Ołdakowska, Agnieszka | Zawadka, Konrad | Coupland, Urszula | Dorobalaura Marques, Małgorzata | Teixeira, Carla | Fernandes, Alexandre | Prata, Filipa | Ene, Luminita | Okhonskaia, Liubov | Voronin, Evgeny | Miloenko, Milana | Labutina, Svetlana | Tomás Ramos, José | Prieto, Luis | Guillén, Sara | Luisa Navarro, María | Saavedra, Jesús | Santos, Mar | Angeles Muñoz, Mª | Ruiz, Beatriz | Mc Phee, Carolina Fernandez | de Ory, Santiago Jimenez | Alvarez, Susana | Ángel Roa, Miguel | Beceiro, José | Martinez, Jorge | Badillo, Katie | Apilanez, Miren | Pocheville, Itziar | Garrote, Elisa | Colino, Elena | Gómez Sirvent, Jorge | Garzón, Mónica | Román, Vicente | Montesdeoca, Abián | Mateo, Mercedes | José Muñoz, María | Angulo, Raquel | Neth, Olaf | Falcón, Lola | Terol, Pedro | Luis Santos, Juan, J. | Moreno, David | Lendínez, Francisco | Grande, Ana | José Romero, Francisco | Lillo, Miguel | Losada, Begoña | Herranz, Mercedes | Bustillo, Matilde | Guerrero, Carmelo | Collado, Pilar | Antonio Couceiro, José | Pérez, Amparo | Isabel Piqueras, Ana | Bretón, Rafael | Segarra, Inmaculada | Gavilán, César | Jareño, Enrique | Montesinos, Elena | Dapena, Marta | Álvarez, Cristina | Gloria Andrés, Ana | Marugán, Víctor | Ochoa, Carlos | Alfayate, Santiago | Isabel Menasalvas, Ana | de Miguel, Elisa | Aebi-Popp, K | Asner, S | Aubert, V. | Battegay, M | Baumann, M | Bernasconi, E | Böni, J | Brazzola, P | Bucher, H | Calmy, A. | Cavassini, M | Ciuffi, A | Duppenthaler, A | Dollenmaier, G | Egger, M | Elzi, L | Fehr, J | Fellay, J | Francini, K | Furrer, H | Fux, C | Grawe, C | Günthard, H | Haerry, D | Hasse, B | Hirsch, H | Hoffmann, M | Hösli, I | Kahlert, C | Kaiser, L. | Keiser, O | Klimkait, Thomas | Kovari, H | Kouyos, R | Ledergerber, B | Martinetti, G | de Tejada, B Martinez | Metzner, K | Müller, N | Nicca, D | Paioni, P | Pantaleo, G | Polli, Ch | Posfay-Barbe, K | Rauch, A | Rudin, C | Schmid, P | Scherrer, A | Speck, R | Tarr, P | Thanh Lecompte, M | Trkola, A | Vernazza, P. | Wagner, N. | Wandeler, G | Weber, R. | Wyler, C | Yerly, S | Techakunakorn, Pornchai | Hansudewechakul, Rawiwan | Kham, Chiang | Wanchaitanawong, Vanichaya | Theansavettrakul, Sookchai | Sai, Mae | Nanta, Sirisak | Ngampiyaskul, Chaiwat | Phanomcheong, Siriluk | Hongsiriwon, Suchat | Karnchanamayul, Warit | Kwanchaipanich, Ratchanee | Kanjanavanit, Suparat | Kamonpakorn, Nareerat | Nantarukchaikul, Maneeratn | Layangool, Prapaisri | Mekmullica, Jutarat | Lucksanapisitkul, Paiboon | Watanayothin, Sudarat | Lertpienthum, Narong | Warachit, Boonyarat | Hanpinitsak, Sansanee | Potchalongsin, Sathit | Thanasiri, Pimpraphai | Krikajornkitti, Sawitree | Attavinijtrakarn, Pornsawan | Srirojana, Sakulrat | Bunjongpak, Suthunya | Puangsombat, Achara | Na-Rajsima, Sathaporn | Ananpatharachai, Pornchai | Akarathum, Noppadon | Phuket, Vachira | Lawtongkum, Weerasak | Kheunjan, Prapawan | Suriyaboon, Thitiporn | Saipanya, Airada | Than-In-At, Kanchana | Jaisieng, Nirattiya | Suaysod, Rapeepan | Chailoet, Sanuphong | Naratee, Naritsara | Kawilapat, Suttipong | Kaleeva, T | Baryshnikova, Y | Soloha, S | Bashkatova, N | Raus, I | Glutshenko, O | Ruban, Z | Prymak, N | Kiseleva, Galyna | Bailey, H | Bamford, Alasdair | Doherty, Conor | Foster, Caroline | Francis, Kate | Harrison, Ian | Kenny, Julia | Letting, Gillian | Murau, Fungai | Nsangi, Edith | Turkova, Anna | Cook, Claire | Crichton, Siobhan | Dobson, Donna | Fairbrother, Keith | M Gibb, Diana | Harper, Lynda | Le Prevost, Marthe | van Looy, Nadine | Peters, Helen | Butler, Karina | Walsh, A. | Thrasyvoulou, L | Welch, Steve | Bernatoniene, J | Manyika, F | Sharpe, G | Subramaniam, B | Sloper, K | Fidler, K | Hague, R | Price, V | Clapson, M | Flynn, J | Cardoso, A | Abou-Rayyah, M | Klein, Nigel | Shingadia, Delane | Gurtin, D | Yeadon, S | Segalc Ball, S | Hawkins, S | Dowie, M | Bandi, S | Percival, E | Eisenhut, M | Duncan, K | Clough, S | Anguvaa, L | Conway, S. | Flood, T | Pickering, A | Murphy, C | Daniels, J., E. | Lees, Y | Thompson, F | Williams, B. | Pope, S | Cliffe, L | Smyth, A | Southall, S | Freeman, A. | Freeman, H | Christie, S | Gordon, A | Rogahn, D | Clarke, L | Jones, L | Offerman, B | Greenberg, M | Benson, C | Riordan, Andrew | Ibberson, L | Shackley, Fiona | Faust, S | Hancock, J | Doerholt, Katja | Prime, Katia | Sharland, M. | Storey, Sharon | Lyall, H | Monrose, C | Seery, P | Tudor-Williams, Gareth | Menson, E | Callaghan, A | Bridgwood, A | Mcmaster, Paddy | Evans, J. | Blake, E | Yannoulias, A | Chappell, Elizabeth | Critchton, Siobhan | Jeannie Collins, Intira | Duff, Charlotte | Giaquinto, Carlo | Goodall, Ruth | Gomezpena, Daniel | Judd, Ali | Lundin, Rebecca | Mangiarini, Laura | Nardone, Alessandra | Thorne, Claire
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CCSD ; Oxford University Press (OUP) -
International audience.
In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART.
