Population pharmacokinetics of FOLFIRINOX: a review of studies and parameters

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Deyme, Laure | Barbolosi, Dominique | Gattacceca, Florence

Edité par CCSD ; Springer Verlag -

International audience. FOLFIRINOX regimen is commonly used in colorectal and more recently pancreatic cancer. However, FOLFIRINOX induces significant and dose-limiting toxic effects leading to empirical dose reduction and sometimes treatment discontinuation. Model-based FOLFIRINOX regimen optimization might help improving patients' outcome. As a first step, the current review aims at bringing together all published population pharmacokinetics models for FOLFIRINOX anticancer drugs.

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