Cyclic nucleotide phosphodiesterase inhibitors prevent aggregation of human platelets by raising cyclic AMP and reducing cytoplasmic free calcium mobilization.

Archive ouverte | Lanza, Francois | CCSD

133. Cyclic nucleotide phosphodiesterase inhibitors (HL-725, RO 15-2041, cilostamide, quercetin and MY-5445) potently inhibit human platelet aggregation induced by ADP. In parallel, PDE inhibitors inhibit the increa...

Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity.

Archive ouverte | Lugnier, Claire | CCSD

Polyindolinic alkaloids from Psychotria forsteriana. Potent inhibitors of the aggregation of human platelets.

Archive ouverte | Beretz, Alain | CCSD