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Antibodies to thrombomodulin induce receptor-mediated endocytosis in human saphenous vein endothelial cells.

Archive ouverte | Brisson, C | CCSD

272. The membrane glycoprotein thrombomodulin (TM) is an essential endothelial cell (EC) cofactor, which forms a 1:1 stoichiometric complex with thrombin. Binding of thrombin to the high affinity TM receptor transfo...

Modulation by cytokines of leukocyte-endothelial cell interactions. Implications for thrombosis.

Archive ouverte | Beretz, Alain | CCSD

225. Endothelial cells play an important role in the regulation of thrombosis. Normal resting (i.e. unstimulated) endothelial cells exhibit antithrombotic activity. This property is due to an active participation of...

Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol ester.

Archive ouverte | Archipoff, G | CCSD

233. Thrombomodulin and tissue-factor activities were measured on the surface of confluent human saphenous-vein endothelial cells (HSVEC) cultivated in 96-multiwell plates. Thrombomodulin activity was measured in th...

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