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NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains

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Klotoe, Bernice J. | Kurepina, Natalia | Zholdibayeva, Elena | Panaiotov, S. | Kreiswirth, Barry N. | Anthony, Richard | Sola, Christophe | Refrégier, Guislaine

Edité par CCSD ; Elsevier -

International audience. The most widely discussed antibiotic-resistant tuberculosis strains ("W" and "B0/W148", "CAO") belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH).

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