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Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

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Kluska, Katarzyna | Peris-Díaz, Manuel David | Płonka, Dawid | Moysa, Alexander | Dadlez, Michał | Deniaud, Aurélien | Bal, Wojciech | Krężel, Artur

Edité par CCSD ; Royal Society of Chemistry -

International audience. Silver (Ag(I)) binding to consensus zinc fingers (ZFs) causes Zn(II) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(I)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.

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