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Reassessing the dosing of cefoxitin prophylaxis during major abdominal surgery: insights from microdialysis and population pharmacokinetic modelling

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Boisson, Matthieu | Torres, Bruna Gaelzer Silva | Yani, Sabrina | Couet, William | Mimoz, Olivier | Dahyot-Fizelier, Claire | Marchand, Sandrine | Grégoire, Nicolas

Edité par CCSD ; Oxford University Press (OUP) -

International audience. Cefoxitin is frequently used for surgical antibiotic prophylaxis (SAP). Using microdialysis, we evaluated whether the currently recommended dosing regimen is appropriate to maintain cefoxitin subcutaneous tissue concentrations above the MIC for pathogens involved in abdominal surgical site infection.

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