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Ligand binding determines whether CD46 is internalized by clathrin coated pits or macropinocytosis.

Archive ouverte | Crimeen-Irwin, B. | CCSD

CD46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for various pathogens, including the measles virus and human herpes virus 6. Ligand binding to CD46 affects (i) protection of autologou...

Octamerization Enables Soluble CD46 Receptor To Neutralize Measles Virus In Vitro and In Vivo

Archive ouverte | Christiansen, D. | CCSD

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Cell surface activation of the alternative complement pathway by the fusion protein of measles virus.

Archive ouverte | Devaux, P. | CCSD

Measles virus (MV)-infected cells are activators of the alternative human complement pathway, resulting in high deposition of C3b on the cell surface. Activation was observed independent of whether CD46 was used as a cellular rece...

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