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Eosinophilic Fasciitis Triggered by Nivolumab: A Remarkable Efficacy of the mTOR Inhibitor Sirolimus

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Le Tallec, Erwan | Lescoat, Alain | Ballerie, Alice | Cador, Berengere | Lena, Hervé | Ricordel, Charles | Sene, Damien | Lebbe, Celeste | Jégo, Patrick | Belhomme, Nicolas

Edité par CCSD ; Lippincott, Williams & Wilkins -

International audience. The global, randomized, double-blind, phase 3 KEYNOTE-189 study(NCT02578680) showed significantly improved OS and PFS with pembrolizumab(pembro)þpemetrexed (pem)þplatinum compared with placeboþpemþplatinumwith a manageable safety profile in pts with previously untreated metastatic nonsqua-mous NSCLC without targetable EGFR/ALK aberrationsj. We present safety and toler-ability data from Japanese pts enrolled in KEYNOTE-189

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