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A structure-toxicity study of Aß42 reveals a new anti-parallel aggregation pathway.

Archive ouverte | Vignaud, Hélène | CCSD

International audience. Amyloid beta (Aβ) peptides produced by APP cleavage are central to the pathology of Alzheimer's disease. Despite widespread interest in this issue, the relationship between the auto-assembly ...

A yeast toxic mutant of HET-s amyloid disrupts membrane integrity

Archive ouverte | Ta, Ha Phuong | CCSD

International audience. Many studies have pointed out the interaction between amyloids and membranes, and their potential involvement in amyloid toxicity. Previously, we generated a yeast toxic amyloid mutant (M8) f...

Microfluidic diffusional sizing probes lipid nanodiscs formation

Archive ouverte | Azouz, Mehdi | CCSD

International audience. Highlights peptide. This confirmed the relevance of using the MDS and nanodiscs as biomimetic models for such investigations.

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