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The cell proliferation antigen Ki-67 organises heterochromatin

Archive ouverte | Sobecki, Michal | CCSD

International audience. Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls h...

Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis

Archive ouverte | Mrouj, Karim | CCSD

International audience. Ki-67 is a nuclear protein that is expressed in all proliferating vertebrate cells. Here, we demonstrate that, although Ki-67 is not required for cell proliferation, its genetic ablation inhi...

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

Archive ouverte | Prieto, Susana | CCSD

International audience. CDK8 and CDK19 form a highly conserved cyclin-dependent kinase subfamily that binds to and inhibits the essential transcription complex, Mediator, and is thought to also activate gene express...

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