Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

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Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

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Edité par CCSD ; Royal Society of Chemistry (RSC) -

International audience. Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell–matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.

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