Head and neck cancer during pregnancy

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Le Guévelou, Jennifer | Lebars, Sabrina | Kammerer, Emmanuel | Gabory, Ludovic | Vergez, Sebastien | Janot, François | Baujat, Bertrand | Righini, Christian, A. | Jegoux, Franck | Dufour, Xavier | Merol, Jean‐claude | Mauvais, Olivier | Lasne‐cardon, Audrey | Selleret, Lise | Thariat, Juliette

Edité par CCSD ; Wiley -

International audience. Background:The incidence of cancer during pregnancy is low but is slightly increas-ing. Data on incidence and etiology of head and neck (HN) cancers in pregnantwomen are rare. We evaluated the frequency, tumor type, associated factors, and spe-cific biomarkers in HN cancers occurring in pregnant (and peripartum) women.Methods:A systematic literature search was performed on PubMed, for any HNtumor site occurring in pregnant women.Results:Sixty cases of HN cancers occurring during pregnancy were identified.Most of them were oral cavity cancers. Relationships with oncogenic viruses, hor-monal disturbance, and shift in maternal immunity profile were identified.Conclusion:Carcinogenesis of HN cancers in pregnant women may be led by dif-ferent cancer type–specific hallmarks. Relevance of these etiological factors withrespect to treatments and birth control recommendations is being investigated bythe REFCOR in an ambispective study.

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