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The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

Archive ouverte | Lacombe, Marie-Lise | CCSD

International audience. Abstract Background Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. R...

Mitochondrial NM23-H4/NDPk-D is Multifunctional: Fueling Mitochondrial GTPase OPA1 and Triggering Mitophagy

Archive ouverte | Schlattner, Uwe | CCSD

International audience. NM23-H4/NDPK-D forms symmetrical homohexameric complexes in the mitochondrial inter-membrane space. The well-established function of NM23-H4 is phosphotransfer activity as a nucleoside diphos...

Nucleoside diphosphate kinase D (NME4) is the first mitochondrial metastasis suppressor

Archive ouverte | Schlattner, Uwe | CCSD

International audience. NDP-kinase D (NME4) is a mitochondrial protein with multiple functions in bioenergetics and signaling. NME4 mainly localizes to the mitochondrial intermembrane space, interacting with cardiol...

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