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Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl– Cotransporter NCC and Transiently Affects Sodium Handling

Archive ouverte | Canonica, Jérémie | CCSD

International audience. Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this pape...

Androglobin, a chimeric mammalian globin, is required for male fertility

Archive ouverte | Keppner, Anna | CCSD

International audience. Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa. Whereas hundreds of genes are...

Plasma Potassium Determines NCC Abundance in Adult Kidney-Specific γENaC Knockout

Archive ouverte | Boscardin, Emilie | CCSD

International audience. The amiloride-sensitive epithelial sodium channel (ENaC) and the thiazide-sensitive sodium chloride cotransporter (NCC) are key regulators of sodium and potassium and colocalize in the late d...

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