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Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter

Archive ouverte | Redhu, Archana Kumari | CCSD

International audience. The molecular basis of polyspecificity of Mdr1p, a major drug/H + antiporter of Candida albicans, is not elucidated. We have probed the nature of the drug-binding pocket by performing systema...

Spontaneous suppressors against debilitating transmembrane mutants of Ca Mdr1 disclose novel interdomain communication via Signature motifs of the Major Facilitator Superfamily

Archive ouverte | Sharma, Suman | CCSD

ABSTRACT The Major Facilitator Superfamily (MFS) includes multiple families of proteins operating as uniporters, symporters and antiporters for a wide spectrum of substrates. Among them, the multidrug resistance-1 drug:H + antipor...

Spontaneous Suppressors Against Debilitating Transmembrane Mutants of CaMdr1 Disclose Novel Interdomain Communication via Signature Motifs of the Major Facilitator Superfamily

Archive ouverte | Sharma, Suman | CCSD

International audience. The Major Facilitator Superfamily (MFS) drug:H+ antiporter CaMdr1, from Candida albicans, is responsible for the efflux of structurally diverse antifungals. MFS members share a common fold of...

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