The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus

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Mirabelli, Carmen | Pelletier, Isabelle | Téoulé, François | Vidalain, Pierre-Olivier | Brisac, Cynthia | Tangy, Frédéric | Delpeyroux, Francis | Blondel, Bruno

Edité par CCSD ; Microbiology Society -

International audience. Poliovirus (PV)-induced apoptosis seems to play a major role in central nervous system (CNS) tissue injury, a crucial feature of the pathogenesis of poliomyelitis. We have previously shown that calcium (Ca2+) flux from the endoplasmic reticulum (ER) to the cytosol during PV infection is involved in apoptosis induction in human neuroblastoma cells. We show here that PV infection is associated with a transient upregulation of Herp (homocysteine-induced ER protein), a protein known to promote the degradation of ER-resident Ca2+ channels. Herp gene transcription is controlled by the transcription factor CREB3 (cAMP response element-binding protein 3). We found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in PV infection. This may reduce the extent of PV-induced damage to the CNS during poliomyelitis.

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