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Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine

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Goeldner, Celia | Lutz, Pierre-Eric | Darcq, Emmanuel | Halter, Thomas | Clesse, Daniel | Ouagazzal, Abdel-Mouttalib | Kieffer, Brigitte, L.

Edité par CCSD ; Elsevier -

International audience. Background-Opiate abuse is a chronic relapsing disorder and maintaining prolonged abstinence remains a major challenge. Protracted abstinence is characterized by lowered mood and clinical studies show elevated co-morbidity between addiction and depressive disorders. At present, their relationship remains unclear and has been little studied in animal models. Here we investigated emotional alterations during protracted abstinence, in mice with a history of chronic morphine exposure.

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