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High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Archive ouverte | Gérard, Annabelle | CCSD

International audience. Mining the antibody repertoire of plasma cells and plasmablasts could enable the discovery of useful antibodies for therapeutic or research purposes1. We present a method for high-throughput,...

H3K27me3 is a determinant of chemotolerance in triple-negative breast cancer

Archive ouverte | Marsolier, Justine | CCSD

Triple-negative breast cancer is associated with the worst prognosis and the highest risk of recurrence among all breast cancer subtypes 1 . Residual disease, formed by cancer cells persistent to chemotherapy, remains one of the m...

H3K27me3 conditions chemotolerance in triple-negative breast cancer

Archive ouverte | Marsolier, Justine | CCSD

International audience. The persistence of cancer cells resistant to therapy remains a major clinical challenge. In triple-negative breast cancer, resistance to chemotherapy results in the highest recurrence risk am...

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