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The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes.

Archive ouverte | Espert, Lucile | CCSD

We have previously shown that ISG20, an interferon (IFN)-induced gene, encodes a 3' to 5' exoribonuclease member of the DEDD superfamily of exonucleases. ISG20 specifically degrades single-stranded RNA. In this report, using immun...

Individual rotavirus-like particles containing 120 molecules of fluorescent protein are visible in living cells

Archive ouverte | Charpilienne, Annie | CCSD

39 ref.. International audience. Rotaviruses are large, complex icosahedral particles consisting of three concentric capsid layers. When the innermost capsid protein VP2 is expressed in the baculovirus-insect cell s...

Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense.

Archive ouverte | Pampin, Mathieu | CCSD

PML nuclear bodies (NBs) are dynamic intranuclear structures harboring numerous transiently or permanently localized proteins. PML, the NBs' organizer, is directly induced by interferon, and its expression is critical for antivira...

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