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Chromosome evolution at the origin of the ancestral vertebrate genome

Archive ouverte | Sacerdot, Christine | CCSD

International audience. Background: It has been proposed that more than 450 million years ago, two successive whole genome duplications took place in a marine chordate lineage before leading to the common ancestor o...

Classification of non-coding variants with high pathogenic impact

Archive ouverte | Moyon, Lambert | CCSD

International audience. Whole genome sequencing is increasingly used to diagnose medical conditions of genetic origin. While both coding and non-coding DNA variants contribute to a wide range of diseases, most patie...

Genome structures resolve the early diversification of teleost fishes

Archive ouverte | Parey, Elise | CCSD

International audience. Accurate species phylogenies are a prerequisite for evolutionary research. Teleosts are by far the largest and the most diversified group of extant vertebrates, but relationships among the th...

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