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Identification and Structural characterization of aapA1/IsoA1 Toxin Antitoxin system from Helicobacter pylori. Identification et caractérisation structurale du système Toxine-Antitoxine aapA1/IsoA1 de Helicobacter pylori : De l’analyse globale des systémes par bio informatique à l’étude structurale par Résonnance Magnétique Nucluéaire

Archive ouverte | Korkut, Dursun Nizam | CCSD

Toxin-antitoxin (TA) systems are present in almost all bacterial genomes. Here we report that the genome of the major human gastric pathogen, Helicobacter pylori, is hosting several copies of a new family of type I TA systems. Sim...

Structural insights into the AapA1 toxin of Helicobacter pylori

Archive ouverte | Korkut, Dursun Nizam | CCSD

International audience. Background: We previously reported the identification of the aapA1/IsoA1 locus as part of a new family of toxinantitoxin (TA) systems in the human pathogen Helicobacter pylori. AapA1 belongs ...

Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures

Archive ouverte | Zhou, Jun | CCSD

International audience. In this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modi...

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