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New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases

Archive ouverte | Lassalle, Louise | CCSD

International audience. Glyoxylate accumulation within cells is highly toxic. In humans, it is associated with hyperoxaluria type 2 (PH2) leading to renal failure. The glyoxylate content within cells is regulated by...

New insights into microbial adaptation to extreme saline environments

Archive ouverte | Vauclare, Pierre | CCSD

International audience. Extreme halophiles are microorganisms adapted to low water activity living at the upper salt concentration that life can tolerate. We review here recent data that specify the main factors, wh...

Allostery and Evolution: A Molecular Journey Through the Structural and Dynamical Landscape of an Enzyme Super Family

Archive ouverte | Coquille, Sandrine | CCSD

International audience. Abstract Allosteric regulation is a powerful mechanism for controlling the efficiency of enzymes. Deciphering the evolutionary mechanisms by which allosteric properties have been acquired in ...

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