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Structure and dynamics of GPCR-bound ghrelin reveal the critical role of the octanoyl chain

Archive ouverte | Ferré, Guillaume | CCSD

International audience

Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain

Archive ouverte | Ferré, Guillaume | CCSD

International audience. Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its rec...

Sodium is a negative allosteric regulator of the ghrelin receptor. Le sodium est un régulateur allostérique négatif du récepteur de la ghréline

Archive ouverte | Ferré, Guillaume | CCSD

International audience. The functional properties of G protein-coupled receptors (GPCRs) are intimately associated with the different components in their cellular environment. Among them, sodium ions have been propo...

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