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Senescence controls prostatic neoplasia driven by Pten loss

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Parisotto, Maxime | Grelet, Elise | El Bizri, Rana | Metzger, Daniel

Edité par CCSD ; Taylor et Francis -

International audience. We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating Pten-deficient cells undergo replication stress and exhibit a DNA damage response, leading to cell senescence, as seen in oncogene-induced senescence.

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