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Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice

Archive ouverte | Drougard, Anne | CCSD

International audience. Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose pr...

Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice.

Archive ouverte | Duparc, Thibaut | CCSD

International audience. Abstract Aims: Apelin and its receptor have emerged as promising targets for the treatment of insulin resistance. Indeed, peripheral administration of apelin stimulates glucose utilization an...

Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes

Archive ouverte | Drougard, Anne | CCSD

Aims: We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. An intracere...

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