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Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.

Archive ouverte | Yuseff, Maria-Isabel | CCSD

Engagement of the B cell receptor (BCR) by surface-tethered antigens (Ag) leads to formation of a synapse that promotes Ag uptake for presentation onto major histocompatibility complex class II (MHCII) molecules. We have highlight...

Medium-throughput image-based phenotypic siRNA screen to unveil the molecular basis of B cell polarization

Archive ouverte | Obino, Dorian | CCSD

International audience. Abstract Cell polarity is an essential and highly conserved process governing cell function. Cell polarization is generally triggered by an external signal that induces the relocation of the ...

Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse

Archive ouverte | Obino, Dorian | CCSD

International audience. Complete activation of B cells relies on their capacity to extract tethered antigens from immune synapses by either exerting mechanical forces or promoting their proteolytic degradation throu...

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